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Title: The Innovative Contributions of Gayle D Wetzel
Introduction
Gayle D Wetzel is a prominent inventor based in Martinez, CA (US). She has made significant contributions to the field of biotechnology, particularly in the development of polypeptides that selectively activate T cells. With a total of 3 patents to her name, Wetzel's work has the potential to impact therapeutic methods for various diseases.
Latest Patents
One of Wetzel's latest patents focuses on IL-2 selective agonists and antagonists. This invention is directed to a polypeptide comprising a human IL-2 mutein, which is numbered in accordance with wild-type IL-2. The mutein is substituted at at least one of positions 20, 88, or 126, allowing it to preferentially activate T cells over NK cells. Notably, the substitutions D20H and I, N88G, I, and R exhibit a relative T cell-differential activity that is significantly greater than that of native IL-2, with predicted reduced in vivo toxicity. The invention also encompasses polynucleotides coding for these muteins, vectors containing the polynucleotides, transformed host cells, pharmaceutical compositions, and therapeutic methods of treatment.
Career Highlights
Throughout her career, Wetzel has worked with notable companies such as Bayer Corporation and Bayer Pharmaceuticals Corporation. Her experience in these organizations has contributed to her expertise in the field of biotechnology and patent development.
Collaborations
Wetzel has collaborated with esteemed colleagues, including Armen B Shanafelt and Jeffrey M Greve. These partnerships have likely enhanced her research and innovation efforts.
Conclusion
Gayle D Wetzel's contributions to the field of biotechnology through her innovative patents demonstrate her commitment to advancing medical science. Her work in developing IL-2 selective agonists and antagonists showcases her role as a leading inventor in her field.