The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 10, 2005
Filed:
Dec. 18, 2001
Christopher C. Lawrence, Fishers, IN (US);
Wei Yuan, Fishers, IN (US);
Armen B. Shanafelt, Carmel, IN (US);
Christopher C. Lawrence, Fishers, IN (US);
Wei Yuan, Fishers, IN (US);
Armen B. Shanafelt, Carmel, IN (US);
Roche Diagnostics Operations, Inc., Indianapolis, IN (US);
Abstract
A method of treating particles to be used in immunoassays reduces interference in particle agglutination assays. For particles having covalently bound antibodies and residual NHS-ester or sNHS-ester groups on the surface, the reactive esters are treated with an aqueous mixture containing an amine compound of formula (I):HN—R—X  (I).The moiety —X is —NH, —OH, or —COCHCH; and R is an alkyl group or an alkyl ether group. When —X is —NHor —COCHCH, R contains from 1 to 20 carbon atoms; and when —X is —OH, R contains from 4 to 20 carbon atoms.