The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 01, 2002
Filed:
Apr. 23, 1999
Applicant:
Inventors:
Armen B. Shanafelt, Moraga, CA (US);
Jeffrey M. Greve, Berkeley, CA (US);
Robert Gundel, Alamo, CA (US);
Assignee:
Bayer Corporation, Berkeley, CA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 1/00 ; C07K 1/400 ; C07K 1/700 ; A61K 4/500 ; A01N 3/718 ;
U.S. Cl.
CPC ...
C07K 1/00 ; C07K 1/400 ; C07K 1/700 ; A61K 4/500 ; A01N 3/718 ;
Abstract
This invention realizes a less toxic IL-4 mutant that allows greater therapeutic use of interleukin 4. Further, the invention is directed to IL-4 muteins having single and double mutations represented by the designators R121E and T13D/R121E, numbered in accordance with wild type IL-4 (His=1). The invention also includes polynucleotides coding for the muteins of the invention, vectors containing the polynucleotides, transformed host cells, pharmaceutical compositions comprising the muteins, and therapeutic methods of treatment.