Andrew L Niles

Title: The Innovative Contributions of Andrew L Niles

Introduction

Andrew L Niles is a prominent inventor based in Madison, WI (US). He has made significant contributions to the field of biochemistry, particularly in the development of novel compounds and methods for enzyme assays. With a total of 14 patents to his name, Niles continues to push the boundaries of scientific innovation.

Latest Patents

One of Niles' latest patents is focused on serum stable pro-coelenterazine analogues. This invention describes pro-coelenterazine analogues, methods for making these analogues, kits comprising the analogues, and methods of using the compounds for the detection of luminescence in luciferase-based assays or fragment complementary luciferase. The disclosed pro-coelenterazine analogues provide increased serum stability for live cell assays and are capable of tuning the brightness and assay windows as needed for various applications.

Another significant patent involves methods for assaying enzyme activities. This invention provides compounds and methods for assaying activities of enzymes such as histone deacetylases and histone acetyltransferases. In some embodiments, the methods may be performed in one step. The compounds described feature peptide-based compounds having at least one blocked lysine or arginine residue, which are coupled to reporter moieties. The methods involve reacting these compounds with an enzyme and an endopeptidase that recognizes basic amino acids to release the reporter moiety, which can then be detected.

Career Highlights

Andrew L Niles is currently employed at Promega Corporation, where he applies his expertise in biochemistry to develop innovative solutions. His work has significantly advanced the field and has practical applications in various scientific research areas.

Collaborations

Niles has collaborated with notable colleagues, including Mary Haak-Frendscho and Terry L Riss. These partnerships have fostered a collaborative environment that enhances the innovation process.

Conclusion

Andrew L Niles is a distinguished inventor whose work has made a lasting impact in the field of biochemistry. His innovative patents and contributions continue to advance scientific research and applications.