The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 17, 2020
Filed:
Jun. 29, 2018
Applicant:
Promega Corporation, Madison, WI (US);
Inventors:
Wenhui Zhou, San Luis Obispo, CA (US);
Brock Binkowski, Sauk City, WI (US);
Poncho Meisenheimer, San Luis Obispo, CA (US);
Andrew L. Niles, Madison, WI (US);
Kevin Kupcho, Madison, WI (US);
James Unch, Arroyo Grande, CA (US);
Assignee:
PROMEGA CORPORATION, Madison, WI (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 487/04 (2006.01); G01N 33/58 (2006.01); C12Q 1/66 (2006.01); G01N 21/76 (2006.01);
U.S. Cl.
CPC ...
C07D 487/04 (2013.01); C12Q 1/66 (2013.01); G01N 33/582 (2013.01); G01N 21/763 (2013.01); G01N 2333/90241 (2013.01); G01N 2333/916 (2013.01);
Abstract
Described are pro-coelenterazine analogues, methods for making the analogues, kits comprising the analogues, and methods of using the compounds for the detection of luminescence in luciferase-based assays or fragment complementary luciferase. The disclosed pro-coelenterazine analogues provide increased serum stability for live cell assays, and are capable of tuning the brightness and assay windows as needed for the applications.