Andrew Henry Huber

Title: **Andrew Henry Huber: Innovator in Fluorescent Probes for Biomedical Applications**

Introduction

Andrew Henry Huber, a notable inventor based in Encinitas, California, has made significant contributions to the field of biochemistry through his innovative patents. With a portfolio of ten patents, Huber has focused primarily on the development of fluorescent probes that serve vital roles in biomedical research and clinical applications.

Latest Patents

Huber's most recent patents showcase his expertise in the utilization of fluorescent probes. One of his inventions details the **development and use of fluorescent probes of unbound bilirubin**. This invention identifies and utilizes proteins that are fluorescently labeled and undergo changes in fluorescence intensity upon binding bilirubin. The probes, which can be labeled at cysteine or lysine residues, as well as at both with two different fluorophores, are essential for accurately determining unbound bilirubin levels in fluid samples.

Another significant patent concerns the **determination of the unbound free fatty acid profiles in biological and industrial specimens**. This invention relates to the profiling of unbound free fatty acids (FFAu) in biological samples—such as human and animal blood specimens—and plant and animal oils. By measuring the fluorescence response of different fluorescently labeled fatty acid binding proteins, which change fluorescence ratios at two wavelengths upon binding an FFAu, researchers can leverage these profiles for applications in human and animal disease, basic research, drug development, and various industrial uses.

Career Highlights

Andrew Huber has had a productive career in the innovation space, particularly focusing on the intersection of fluorescent technology and biochemical applications. His dedication to advancing the understanding of unbound metabolites has made significant impacts across various research domains.

Collaborations

Throughout his career, Huber has collaborated with esteemed colleagues such as Alan Marc Kleinfeld and James Patrick Kampf. These collaborations have undoubtedly contributed to his successful research and the development of his patented technologies.

Conclusion

Andrew Henry Huber stands out as an influential inventor in the field of fluorescent probes, with a commendable track record of ten patents. His innovative work in determining unbound bilirubin levels and free fatty acid profiles illustrates the important intersection of technology and biochemical research, highlighting the ongoing need for innovation in understanding biological systems.