The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 20, 2015
Filed:
Oct. 26, 2007
Alan Marc Kleinfeld, La Jolla, CA (US);
Andrew Henry Huber, Encinitas, CA (US);
James Patrick Kampf, San Diego, CA (US);
Thomas Kwan, San Diego, CA (US);
Baolong Zhu, San Diego, CA (US);
Alan Marc Kleinfeld, La Jolla, CA (US);
Andrew Henry Huber, Encinitas, CA (US);
James Patrick Kampf, San Diego, CA (US);
Thomas Kwan, San Diego, CA (US);
Baolong Zhu, San Diego, CA (US);
Other;
Abstract
Methods of determining levels of unbound metabolites are disclosed. Probes derived from fatty acid binding protein muteins are described that bind preferentially to a number of unbound metabolites including oleate, stearate, linoleate, palmitate, arachidonate and unconjugated bilirubin. A profile for a patient is determined using one or more of the described probes. The profile is useful in diagnosis of disease, particularly myocardial infarction, non-alcoholic fatty liver disease (NAFLD), diabetes, stroke, sepsis and neonatal jaundice. The responses of multiple probes to a test sample are used to classify the degree of acute coronary syndrome by comparison to multi-probe profiles generated from unstable angina, non ST elevation myocardial infarction, and ST elevation myocardial infarction.