The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 25, 2002
Filed:
Jun. 05, 1995
David Baltimore, New York, NY (US);
Ranjan Sen, Cambridge, MA (US);
Phillip A. Sharp, Newton, MA (US);
Harinder Singh, Chicago, IL (US);
Louis Staudt, Silver Springs, MD (US);
Jonathan H. Lebowitz, Zionsville, IN (US);
Albert S. Baldwin, Jr., Chapel Hill, NC (US);
Roger G. Clerc, Binningen, CH;
Lynn M. Corcoran, Port Melbourne, AU;
Patrick A. Baeuerle, Eichenau, DE;
Michael J. Lenardo, Potomac, MD (US);
Chen-Ming Fan, San Francisco, MA (US);
Thomas P. Maniatis, Belmont, MA (US);
Other;
Abstract
Constitutive and tissue-specific protein factors which bind to transcriptional regulatory elements of Ig genes (promoter and enhancer) are described. The factors were identified and isolated by an improved assay for protein-DNA binding. Genes encoding factors which positively regulate transcription can be isolated and employed to enhance transription of Ig genes. In particular, NF-kB, the gene encoding NF-kB, IkB and the gene encoding IkB and uses therefor.