The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 31, 1996
Filed:
Jun. 07, 1995
Bruce W Stillman, Cold Spring Harbor, NY (US);
Stephen P Bell, Cold Spring Harbor, NY (US);
Ryuji Kobayashi, Cold Spring Harbor, NY (US);
Jasper Rine, Moraga, CA (US);
Margit Foss, Durham, NC (US);
Francis J McNally, Davis, CA (US);
Patricia Laurenson, San Francisco, CA (US);
Ira Herskowitz, Berkeley, CA (US);
Joachim Li, San Francisco, CA (US);
Kimberly Gavin, Cold Spring Harbor, NY (US);
Masumi Hidaka, Cold Spring Harbor, NY (US);
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY (US);
The Regents of the University of California, Oakland, CA (US);
Abstract
Origin of Replication Complex (ORC) genes, nucleic acids which encode ORC proteins and hybridization reagents, probes and primers capable of hybridizing with ORC genes and methods for screening chemical libraries for lead compounds for pharmacological agents useful in the diagnosis or treatment of disease associated undesirable cell growth are provided. An exemplary screen involves forming a mixture comprising a recombinant ORC protein, a natural intracellular ORC protein binding target, and a candidate pharmacological agent; incubating the mixture under conditions whereby, but for the presence of said candidate pharmacological agent, said ORC protein selectively binds said binding target; and detecting the presence or absence of specific binding of said ORC protein to said binding target.