Francis J McNally

Title: The Innovations of Francis J McNally

Introduction

Francis J McNally is a notable inventor based in Davis, CA (US). He has made significant contributions to the field of molecular biology, particularly in the study of the origin of replication complex genes. With a total of 2 patents, his work has implications for understanding cell growth and developing pharmacological agents.

Latest Patents

McNally's latest patents focus on the Origin of Replication Complex (ORC) genes. These patents detail nucleic acids that encode ORC proteins and hybridization reagents, probes, and primers capable of hybridizing with ORC genes. The methods described in these patents involve screening chemical libraries for lead compounds that can be useful in diagnosing or treating diseases associated with undesirable cell growth. An exemplary screening process includes forming a mixture of a recombinant ORC protein, a natural intracellular ORC protein binding target, and a candidate pharmacological agent. The mixture is incubated under specific conditions to detect the binding of the ORC protein to the target, which is influenced by the presence of the candidate agent.

Career Highlights

Throughout his career, McNally has worked with prestigious institutions such as Cold Spring Harbor Laboratory and the University of California. His research has contributed to advancements in understanding the molecular mechanisms of cell replication and growth.

Collaborations

Some of McNally's notable coworkers include Bruce W Stillman and Stephen P Bell. Their collaborative efforts have furthered research in the field of molecular biology and genetics.

Conclusion

Francis J McNally's innovative work in the area of ORC genes and their applications in pharmacology highlights his significant contributions to science. His patents and collaborations reflect a commitment to advancing our understanding of cell growth and disease treatment.