Company Filing History:
5 out of 190 
2 out of 5,452 
2 out of 15,488 
Years Active: 1996-2014
Title: Bruce W Stillman: Innovator in Cancer Research
Introduction
Bruce W Stillman is a prominent inventor based in Cold Spring Harbor, NY (US). He has made significant contributions to the field of cancer research, holding a total of six patents. His work focuses on innovative methods for treating chemotherapy-resistant leukemia and other cancers.
Latest Patents
One of his latest patents involves the identification of RNA interference (RNAi) targets and the use of RNAi for rational therapy of chemotherapy-resistant leukemia and other cancers. This patent provides a mosaic mouse model that is instrumental in determining the potency of short hairpin RNA (shRNA) in vivo for reducing the survival of cancer cells in chemotherapy-resistant leukemia. The model includes a syngeneic mouse recipient that is transplanted with tet-on competent leukemia cells carrying a bicistronic nucleic acid construct. This construct comprises a promoter operably linked to a fusion gene associated with chemotherapy-resistant leukemia, along with a sequence encoding a reverse tet-transactivator protein, allowing for co-expression of both coding sequences from the promoter.
Another significant patent pertains to methods of immunoassay for human CDC6. This invention focuses on novel genes that regulate DNA replication and the entry of a cell into mitosis. It also includes novel proteins encoded by these genes, antibodies that bind to the encoded protein, and homologs of the novel genes. The invention encompasses methods for determining the presence of a proliferative disorder by assessing the levels of hscdc6.
Career Highlights
Bruce W Stillman has had a distinguished career, working with esteemed institutions such as Cold Spring Harbor Laboratory and the University of Texas System. His research has been pivotal in advancing our understanding of cancer biology and treatment.
Collaborations
Throughout his career, he has collaborated with notable colleagues, including R Sanders Williams and Stephen P Bell. These partnerships have contributed to the success of his research endeavors.
Conclusion
In summary, Bruce W Stillman is a key figure in cancer research, with a focus on innovative therapies for chemotherapy-resistant leukemia. His patents and collaborations reflect his commitment to advancing medical science and improving patient outcomes.