Zhang Yang

Title: Innovations of Zhang Yang in Glycoengineering

Introduction

Zhang Yang is a prominent inventor based in Vanløse, Denmark, known for his significant contributions to the field of glycoengineering. With a total of five patents to his name, he has made remarkable advancements in the modification of lysosomal enzymes, which have important therapeutic applications.

Latest Patents

Zhang Yang's latest patents include innovative methods for modifying lysosomal enzymes through cell-based techniques. One of his notable inventions focuses on lysosomal enzymes that are modified to have low Man6P and low exposed Mannose, while exhibiting a high sialic acid content of the alpha2,3 type. This modification enables a longer circulation time and improved uptake into challenging organs such as the heart, kidney, and brain. Another significant patent involves modified recombinant lysosomal alpha-galactosidase A and aspartylglucoaminidase, which also feature low mannose-6-phosphate and high sialic acid content, enhancing their therapeutic potential.

Career Highlights

Throughout his career, Zhang Yang has worked with esteemed institutions, including the University of Copenhagen and Glycodisplay ApS. His research has focused on the therapeutic applications of modified lysosomal enzymes, contributing to advancements in medical treatments.

Collaborations

Zhang has collaborated with notable colleagues such as Henrik Clausen and Claus Kristensen, further enhancing the impact of his research in the field of glycoengineering.

Conclusion

Zhang Yang's innovative work in modifying lysosomal enzymes through glycoengineering has the potential to revolutionize therapeutic approaches for difficult-to-reach organs. His contributions are significant in advancing medical science and improving patient outcomes.