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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10889845 B1

PDFFull Text
Date of Patent:
Jan. 12, 2021

Filed:

Jun. 15, 2016

Production of n-glycoproteins for enzyme assisted glycomodification

Applicants:

University of Copenhagen, Copenhagen K, DK;

Danmarks Tekniske Universitet, Kgs. Lyngby, DK;

Inventors:

Shamim Herbert Rahman, Valby, DK;

Carsten Behrens, Copenhagen N, DK;

Malene Bech Vester-Christensen, Vedbæk, DK;

Henrik Clausen, Holte, DK;

Zhang Yang, Vanløse, DK;

Adnan Fevzi Halim, Malmö, SE;

Eric Bennett, Kgs. Lyngby, DK;

Assignees:

UNIVERSITY OF COPENHAGEN, Copenhagen, DK;

DANMARKS TEKNISKE UNIVERSITET, Kgs. Lyngby, DK;

Attorney:

Knobbe, Martens, Olson & Bear, LLP

Primary Examiner:

Shin Lin Chen

Int. Cl.
CPC ...
A61K 48/00 (2006.01); C07H 21/04 (2006.01); C12P 21/00 (2006.01); C07K 14/505 (2006.01); C07K 14/61 (2006.01); C07K 16/00 (2006.01); C12N 15/90 (2006.01); C12N 9/64 (2006.01); C12N 5/00 (2006.01); C12N 5/071 (2010.01);
U.S. Cl.
CPC ...
C12P 21/005 (2013.01); C07K 14/505 (2013.01); C07K 14/61 (2013.01); C07K 16/00 (2013.01); C12N 5/00 (2013.01); C12N 5/0682 (2013.01); C12N 9/6437 (2013.01); C12N 15/907 (2013.01); C07H 21/04 (2013.01); C07K 2317/41 (2013.01); C12N 2501/724 (2013.01); C12N 2510/02 (2013.01);
Abstract

The present invention relates to a cell comprising a gene encoding a polypeptide of interest, wherein the polypeptide of interest is expressed comprising one or more posttranslational modification patterns. These modifications are useful for example in improvement of pharmacokinetic properties, i.e. by attaching PEG chains to proteins. The present invention also relates to methods for producing the antibodies and compositions comprising the antibodies, and their uses.

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