The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 25, 2023
Filed:
Aug. 29, 2019
University of Copenhagen, Copenhagen K, DK;
Glycodisplay Aps;
Claus Kristensen, Bronshoj, DK;
Weihua Tian, Hvidovre, DK;
Henrik Clausen, Copenhagen, DK;
Zhang Yang, Gentofte, DK;
Sergey Vakhrushev, Nyborg, DK;
University of Copenhagen, Copenhagen, DK;
GLYCODISPLAY APS, Copenhagen, DK;
Abstract
The present invention relates to lysosomal enzymes modified by use of cell based methods, a compositions comprising a modified lysosomal enzyme, as well as methods for producing a modified lysosomal enzyme and therapeutic use of such modified lysosomal enzyme. In particular, the present disclosure relates to a modified lysosomal enzyme which has low Man6P and low exposed Mannose and high sialic acid content of alpha2,3 type enabling long circulation time and improved uptake into difficult-to-reach organs like heart, kidney and brain.