Company Filing History:
2 out of 77 
2 out of 2 Years Active: 2023-2025
Title: Weihua Tian: Innovator in Lysosomal Enzyme Modification
Introduction
Weihua Tian is an accomplished inventor based in Hvidovre, Denmark. With a singular patent to his name, Tian has made significant contributions to the field of biochemistry, specifically in the modification of lysosomal enzymes. His innovative work focuses on enhancing enzyme efficacy for therapeutic applications.
Latest Patents
Weihua Tian's notable patent is titled "Modified recombinant lysosomal alpha-galactosidase A and aspartylglucoaminidase having low mannose-6-phosphate and high sialic acid." This invention relates to the modification of lysosomal enzymes using cell-based methods. The patent also encompasses compositions that include modified lysosomal enzymes and outlines methods for their production and therapeutic use. Notably, the modified lysosomal enzymes demonstrate low Man6P and low exposed mannose, alongside high sialic acid content of the alpha2,3 type. These modifications enable prolonged circulation time and improved uptake in challenging organs such as the heart, kidneys, and brain.
Career Highlights
Weihua Tian has had an impressive career, contributing his expertise to prominent research institutions and companies. His academic journey includes a significant association with the University of Copenhagen, where he engaged in groundbreaking research. Additionally, he worked with Glycodisplay ApS, a company focusing on glyco-engineering solutions for therapeutic applications.
Collaborations
Throughout his career, Tian has collaborated with notable colleagues, including Claus Kristensen and Henrik Clausen. These partnerships have aided in the advancement of his research and have fostered an environment of innovation and shared knowledge in the field of lysosomal enzyme modification.
Conclusion
Weihua Tian exemplifies the spirit of innovation in biochemistry through his pioneering work in lysosomal enzyme modification. His contributions have the potential to significantly impact therapeutic strategies for various organ-specific diseases. With a strong foundation in research and collaboration, Tian continues to push the boundaries of science and technology in enzyme therapies.
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