Location History:
- Takasago, JP (1994 - 2001)
- Kobe, JP (2002)
- Himeji, JP (1993 - 2004)
- Hyogo, JP (2001 - 2006)
Company Filing History:
11 out of 1,704 
7 out of 698 
1 out of 212 Years Active: 1993-2006
Title: **Yoshihide Fuse: Innovator in Optically Active Amino Acids and Cancer Treatment**
Introduction
Yoshihide Fuse, based in Himeji, Japan, is a prominent inventor with a remarkable portfolio of 19 patents. His innovative work primarily focuses on the production of optically active amino acids and novel methods for cancer treatment, demonstrating his commitment to advancing the fields of biochemistry and medicinal chemistry.
Latest Patents
One of Yoshihide Fuse's latest patents involves a sophisticated **process for producing optically active amino acid derivatives**. This method involves N-protecting an optically active 3-haloalanine derivative followed by cyclization, or cyclizing this derivative followed by N-protection. The result is an optically active N-protected-aziridine-2-carboxylic acid derivative, protected by a benzenesulfonyl group that is substituted by nitro groups at the 2 and/or 4 positions. This innovative process allows for the production of both natural and unnatural optically active amino acids from inexpensive materials using straightforward procedures.
Another significant contribution from Fuse includes a patent for **methods of treating cancer using a heat shock factor activity inhibitor**. This treatment works by controlling the expression of proteins induced by a heat shock factor. A novel compound, benzo-1,3-dioxole, acts as an inhibitor of heat shock factor activity, effectively inhibiting the transcription of structural genes regulated by this factor. This breakthrough not only presents a potential drug for treating or preventing cancer through thermotherapy, but also addresses stress-related diseases such as depression.
Career Highlights
Yoshihide Fuse has worked with esteemed companies, including Kaneka Corporation and Kanegafuchi Kagaku Kogyo Kabushiki Kaisha, where he has made significant contributions to research and development. His expertise in biochemistry has led to several innovations that have the potential to benefit both health care and the pharmaceutical industry.
Collaborations
Throughout his career, Yoshihide Fuse has collaborated with notable professionals in the field, including Tadashi Moroshima and Yasuyoshi Ueda. These collaborations have played a crucial role in the progression of his work and the successful development of his patented technologies.
Conclusion
Yoshihide Fuse stands out as an influential inventor in the realm of optically active amino acids and cancer treatments. With 19 patents that reflect his dedication to innovation, Fuse’s work not only pushes the boundaries of scientific research but also holds the promise of significant advancements in therapeutic applications. His contributions continue to inspire future research and development in these critical areas.