Company Filing History:
4 out of 1,195 
1 out of 125 Years Active: 2013-2022
Title: Yi-Jang Lee: Innovator in Cellular Senescence and Fluorescent Fusion Proteins
Introduction
Yi-Jang Lee is a prominent inventor based in Taipei, Taiwan. He has made significant contributions to the fields of cellular senescence and fluorescent proteins, holding a total of 5 patents. His innovative work has implications for both medical research and biotechnology.
Latest Patents
One of Yi-Jang Lee's latest patents is a method for the treatment of cellular senescence. This invention provides an alcohol extract of Nakai ex Murata, which exhibits significant effects on inhibiting senescence in human WI-38 lung fibroblasts and human dermal fibroblasts. The alcohol extract is capable of suppressing the expression of cofilin-1, a protein involved in actin dynamics and cell morphology, which is found to be increased in senescent cells. The suppression effect of cell senescence by this herb extract is more efficient at mild concentrations without over-inhibition of cell viability and growth.
Another notable patent is related to a fluorescent fusion protein. This invention comprises a first fluorescent protein with a first emission wavelength, a second fluorescent protein with a second excitation wavelength and second emission wavelength, and a linker peptide connecting the two proteins. The first emission wavelength overlaps the second excitation wavelength, allowing the second fluorescent protein to exhibit its emission wavelength after receiving energy. This fluorescent fusion protein demonstrates stronger fluorescence in the absence of biliverdin (BV).
Career Highlights
Yi-Jang Lee has worked with esteemed institutions such as National Yang Ming Chiao Tung University and the Institute of Nuclear Energy Research, Atomic Energy Council, Executive Yuan. His work in these organizations has allowed him to further his research and contribute to advancements in his fields of expertise.
Collaborations
Some of Yi-Jang Lee's notable coworkers include Cheng-Han Tsai and Liang-Ting Lin. Their collaborative efforts have likely enhanced the impact of his research and innovations.
Conclusion
Yi-Jang Lee is a distinguished inventor whose work in cellular senescence and fluorescent fusion proteins has made significant strides in scientific research. His contributions continue to influence the fields of biotechnology and medical research.
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