National Yang Ming Chiao Tung University

Institute of Nuclear Energy Research, Atomic Energy Council, Executive Yuan

Yi-Jang Lee

Cheng-Han Tsai

Liang-Ting Lin

Jyh-Cheng Chen

Yun-Lian Lin

Chun-Yuan Chang

Te-Wei Lee

Wei-Hsiang Hsu

Shu-Pei Chiu

Chung-Sheng Huang

Jem-Mau Lo

Shiau-Yi Wang

Bing-Ze Lin

Bo-Sheng Wang

Feng-Yun Huang

Pin-Ho Lo

Yuan-Heng Tu

CAllen Chang

Bo-Sian Lin

The present invention provides an alcohol extract ofNakai ex Murata exhibits significant effects on inhibiting the senescence in human WI-38 lung fibroblasts and human dermal fibroblasts. Moreover, the alcohol extract ofis able to suppress the expression of the cofilin-1, a protein involved in actin dynamics and cell morphology and found to be increased in senescent cells. Suppression effect of cell senescence by this herb extract is more efficient in mild concentration without over-inhibition of cell viability and growth.

Method for treatment of cellular senescence

A fluorescent fusion protein is provided. The fluorescent fusion protein of the invention comprises a first fluorescent protein with first emission wavelength, a second fluorescent protein with second excitation wavelength and second emission wavelength, and a linker peptide linking the first fusion protein and the second fusion protein, wherein the first emission wavelength overlaps the second excitation wavelength so that the second fluorescent protein exhibits the second emission wavelength after receiving energy. The fluorescent fusion protein of the invention exhibits a stronger fluorescence in the absence of bilivirdin (BV).

Fluorescent fusion protein

The invention relates to a kit for preparation of target radiopharmaceuticals, a method of using the kit to prepare target radiopharmaceuticals and use of the target radiopharmaceuticals. The target radiopharmaceuticals comprise a radio-nuclear loading on liposome and inhibit the tumor growth and metastatic progression of head and neck cancer, lung cancer and brain cancer. The radiopharmaceuticals may be used for treating the mentioned cancers.

Kit for preparation of target radiopharmaceuticals and method of using it

The present invention relates to a method for detecting cancer initiating cells in living animal body by multimodality reporter gene imaging. In the method of this invention, cells escaping from cell loss during tumor enlargement are identified as cancer initiating cells.

Methods for in vivo identification of cancer initiating cells by multimodality reporter gene imaging

The present invention discloses a concept that the expression level of cofilin may reflect the senescent condition of a cell or tissue. According to the findings in present invention, a method for determining the cellular senescent condition in a cell or tissue sample by evaluating the expression level of cofilin is provided. The detection of the expression level of cofilin is also used to screen an effective compound or composition for regulating the senescent condition in target cells.

Method for evaluating cell aging by expression level of cofilin

Growing community of inventors

Taipei, Taiwan

Yi-Jang Lee