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Title: Yasuko Honjo: Innovator in T Cell Receptor Technology
Introduction
Yasuko Honjo is a prominent inventor based in Hiroshima, Japan. She has made significant contributions to the field of immunology, particularly in the development of techniques related to T cell receptors. With a total of two patents to her name, her work is paving the way for advancements in therapeutic applications.
Latest Patents
Honjo's latest patents include a full replacement technique for T cell receptors using platinum TALEN. This innovative technique eliminates the influence of endogenous TCRs in TCR gene transfer. By editing a TCR gene with a genome editing enzyme that has specific amino acid patterns, the method avoids mispairing with endogenous TCRs and reduces the risk of self-reactive TCRs. Another notable patent is a technique for creating antigen-specific regulatory T cells (Treg) using effector T cell antigen receptors. This method involves identifying a TCR clone in an effector T cell population and introducing the relevant nucleic acid sequences into regulatory T cells, ensuring they are expressed in pairs.
Career Highlights
Yasuko Honjo has worked with esteemed institutions such as Hiroshima University and Repertoire Genesis Incorporation. Her research has significantly impacted the understanding and manipulation of T cell responses, contributing to the development of targeted immunotherapies.
Collaborations
Honjo has collaborated with notable colleagues, including Tatsuo Ichinohe and Takashi Yamamoto. Their combined expertise has further advanced the research in T cell receptor technology.
Conclusion
Yasuko Honjo's innovative work in T cell receptor technology exemplifies her dedication to advancing immunological research. Her patents reflect her commitment to developing effective therapeutic strategies for various diseases.