The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 03, 2023
Filed:
Oct. 09, 2018
Hiroshima University, Higashi-Hiroshima, JP;
Repertoire Genesis Incorporation, Ibaraki, JP;
Tatsuo Ichinohe, Hiroshima, JP;
Takashi Yamamoto, Higashi-Hiroshima, JP;
Tetsushi Sakuma, Higashi-Hiroshima, JP;
Yasuko Honjo, Hiroshima, JP;
Takakazu Kawase, Hiroshima, JP;
Takahiko Miyama, Hiroshima, JP;
Ryuji Suzuki, Ibaraki, JP;
Hiroshima University, Higashi-Hiroshima, JP;
Reperptoire Genesis Incorpration, Ibaraki, JP;
Abstract
The present disclosure provides a technique for producing regulatory T cells specific to a desired antigen. Regulatory T cells specific to an antigen are produced by a method that includes: a step for identifying a T cell receptor (TCR) clone present in an effector T cell population specific to an antigen in an effector T cell donor; and a step for introducing all or part of the nucleic acid sequence of the TCRα gene and all or part of the nucleic acid sequence of the TCRβ gene included in the clone into a regulatory T cell, said step comprising introducing the TCRα and the TCRβ so as to be expressed in pairs.