Location History:
- Gotemba, JP (2010)
- Gotenba, JP (2012 - 2014)
- Shizuoka, JP (2007 - 2016)
Company Filing History:
Years Active: 2007-2016
Title: Yasufumi Kikuchi: Innovator in Antibody Research
Introduction
Yasufumi Kikuchi is a prominent inventor based in Gotenba, Japan, known for his significant contributions to the field of antibody research. With a total of five patents to his name, Kikuchi has made remarkable advancements in the understanding and application of structural isomers in antibody compositions.
Latest Patents
Kikuchi's latest patents include innovative work on structural isomers of sc(Fv)2. This invention focuses on the separation of structural isomers in sc(Fv)2 compositions of anti-human Mpl antibody and humanized anti-human Mpl antibody. The obtained structural isomers were cleaved at their linkers to confirm their classification as single chain diabody type and bivalent scFv type. Notably, the agonistic activities of these structural isomers were found to be significantly different. Furthermore, Kikuchi discovered that the content ratio of the structural isomers in sc(Fv)2 compositions could be regulated by altering temperature, modifying the lengths of the linkers of sc(Fv)2, or adjusting amino acids in their variable regions. Another significant patent involves the development of humanized anti-CD47 antibodies. This invention relates to humanized antibodies binding to CD47 and includes diabodies characterized by a disulfide bond between diabody-forming fragments. The patent also covers genes encoding these antibodies, vectors containing said genes, host cells containing said vectors, and processes for preparing antibodies, which are crucial for therapeutic agents targeting hematological disorders.
Career Highlights
Throughout his career, Yasufumi Kikuchi has worked with notable companies such as Chugai Seiyaku Kabushiki Kaisha and Zenyth Operations Pty. Ltd. His work in these organizations has contributed to the advancement of antibody therapies and innovations in the field.
Collaborations
Kikuchi has collaborated with esteemed colleagues, including Shinsuke Uno and Naoshi Fukushima. These partnerships have fostered a collaborative environment that enhances research and development in antibody technology.
Conclusion
Yasufumi Kikuchi's contributions to antibody research and his innovative patents highlight his role as a leading inventor in the field. His work continues to influence advancements in therapeutic applications and antibody engineering.