Yaroslava Georgievna Yingling

Title: Yaroslava Georgievna Yingling: Innovator in Biochemical Engineering

Introduction

Yaroslava Georgievna Yingling is a prominent inventor based in Cary, NC (US). He has made significant contributions to the field of biochemical engineering, particularly in the development of innovative enzyme variants and RNA nanoparticles. With a total of 2 patents, his work has the potential to impact therapeutic and diagnostic applications.

Latest Patents

Yingling's latest patents include two groundbreaking inventions. The first patent focuses on CALB variants, which are amino acid sequence variants of a lipase that exhibit improved activity for catalyzing synthesis reactions. The methods for preparing these variants involve predicting amino acid sites for change based on computational models of the protein structure in non-aqueous conditions. The enzyme sequence variants described in this patent demonstrate a three to nine-fold improvement in synthesis activity over the parent protein sequence. The second patent pertains to RNA nanoparticles and nanotubes, providing polyvalent RNA nanoparticles that utilize RNA motifs as building blocks to form RNA nanotubes. These nanoparticles are suitable for therapeutic or diagnostic use in various diseases or disorders.

Career Highlights

Throughout his career, Yingling has worked with esteemed organizations such as the National Institutes of Health, a component of the US Department of Health & Human Services, and the University of California. His experience in these institutions has allowed him to collaborate with leading experts in the field and contribute to significant advancements in biochemical research.

Collaborations

Yingling has collaborated with notable colleagues, including Bruce Allen Shapiro and Eckart Bindewald. These partnerships have further enriched his research and innovation efforts.

Conclusion

Yaroslava Georgievna Yingling is a distinguished inventor whose work in enzyme variants and RNA nanoparticles showcases his commitment to advancing biochemical engineering. His contributions have the potential to lead to significant breakthroughs in therapeutic and diagnostic applications.