Company Filing History:
5 out of 91 
2 out of 1,187 
Years Active: 2008-2017
Title: **Innovations of Yangbo Feng: A Pioneer in Kinase Inhibition**
Introduction
Yangbo Feng, based in Palm Beach Gardens, Florida, has made significant contributions to the field of biochemistry and pharmaceuticals, holding a total of seven patents. His innovative work primarily focuses on developing selective inhibitors that address critical medical concerns such as Parkinson's disease and platelet aggregation disorders.
Latest Patents
Among Yangbo Feng's most recent patents are two noteworthy inventions:
1. **Bidentate-binding modulators of LRRK2 and JNK kinases**: This invention provides novel dual inhibitors targeting both JNK and LRRK2, kinases associated with Parkinson’s disease and myocardial infarction. The unique bidentate-binding strategy enhances the inhibitors' potency and selectivity. For instance, Compound 6 has shown impressive results, exhibiting a potent IC50 value of 12 nM against JNK3 and a modest value of 99 nM against LRRK2-G2019S. Additionally, it effectively inhibited LRRK2:G2019S induced mitochondrial dysfunction in SHSY5Y cells while remaining selective against a diverse panel of kinases.
2. **Non-nucleotide composition for inhibiting platelet aggregation**: This breakthrough method targets conditions related to platelet aggregation, including thrombosis. It involves the administration of pharmaceutical compositions with non-nucleotide compounds, particularly P2Y receptor antagonists, to effectively inhibit platelet aggregation. The invention outlines novel compounds that present significant therapeutic potential in treating related disorders.
Career Highlights
Yangbo Feng has a robust career, having worked at renowned institutions such as Inspire Pharmaceuticals and The Scripps Research Institute. His expertise in kinase research and medicinal chemistry has played a crucial role in advancing therapeutic solutions for complex medical issues.
Collaborations
Throughout his career, Yangbo Feng has collaborated with notable professionals, including Robert Plourde, Jr. and Sammy Ray Shaver. These partnerships have facilitated the shared pursuit of innovation and the development of groundbreaking medical solutions in their field.
Conclusion
Yangbo Feng's contributions to the scientific community through his patents demonstrate his commitment to addressing significant health challenges. With his innovative discoveries in kinase inhibition and platelet aggregation, he continues to pave the way for future therapeutic advancements, underscoring the vital role of inventors in the field of medicine.