Xuezhi Yin

Title: Xuezhi Yin: Innovator in Pharmaceutical Formulations

Introduction

Xuezhi Yin is a notable inventor based in Changzhou, China, recognized for his contributions to pharmaceutical formulations. With a total of two patents to his name, he has made significant advancements in the preparation of itraconazole and aliskiren intermediates.

Latest Patents

Xuezhi Yin's latest patents include a method for preparing an itraconazole formulation. This innovative method involves dissolving a mixture of itraconazole and L-ascorbic acid in a mixed solvent of dichloromethane and methanol. The process continues with the addition of hydroxypropyl methylcellulose and pluronic F-127, followed by dichloromethane to create a raw material solution. The solution is then subjected to supercritical fluid crystallization, resulting in composite particles with decreased particle size and increased bioavailability. Additionally, he has developed methods for the preparation of pharmaceutical intermediates of aliskiren. These methods improve upon prior art by eliminating the need for column chromatography, thus facilitating large-scale industrial production. The resulting products can be purified through recrystallization or vacuum distillation, ensuring high chemical purity.

Career Highlights

Throughout his career, Xuezhi Yin has worked with prominent companies such as Changzhou Pharmaceutical Factory Co., Ltd. and Crystec Ltd. His experience in these organizations has contributed to his expertise in pharmaceutical development and innovation.

Collaborations

Xuezhi has collaborated with notable coworkers, including Bing Wang and Linda Sharon Daintree, enhancing his research and development efforts in the pharmaceutical field.

Conclusion

Xuezhi Yin's innovative work in pharmaceutical formulations has led to significant advancements in drug preparation methods. His contributions continue to impact the industry positively, showcasing the importance of innovation in healthcare.