The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 16, 2019
Filed:
Sep. 08, 2015
Changzhou Pharmaceutical Factory Co., Ltd., Changzhou, CN;
Crystec Ltd., Bradford, GB;
Xuezhi Yin, Changzhou, CN;
Linda Sharon Daintree, Bradford, GB;
Sheng Ding, Changzhou, CN;
Daniel Mark Ledger, Bradford, GB;
Bing Wang, Changzhou, CN;
Wenwen Zhao, Changzhou, CN;
Wei Wu, Changzhou, CN;
Jiansheng Han, Changzhou, CN;
CHANGZHOU PHARMACEUTICAL FACTORY CO., LTD., Changzhou, CN;
CRYSTEC LTD., Bradford, GB;
Abstract
A method for preparing an itraconazole formulation including: dissolving a mixture of itraconazole and L-ascorbic acid with a mixed solvent of dichloromethane and methanol, adding a hydroxypropyl methylcellulose and a pluronic F-127 and then dichloromethane into the mixed solvent to obtain a raw material solution; feeding a carbon dioxide into a crystallization autoclave in a supercritical fluid crystallization equipment system through a pressure regulating valve; spraying the solution into the crystallization autoclave via a spray nozzle, separating out composite particles from the solution and collecting the composite particles at a bottom of the crystallization autoclave, and encapsulating the composite particles to obtain a itraconazole formulation with decreased particle size and increased bioavailability.