Jiansheng Han

Title: Jiansheng Han: Innovator in Pharmaceutical Formulations

Introduction

Jiansheng Han is a notable inventor based in Changzhou, China. He has made significant contributions to the field of pharmaceutical formulations, particularly through his innovative methods of preparing itraconazole preparations. His work has implications for improving the bioavailability of medications, which is crucial for effective treatment.

Latest Patents

Jiansheng Han holds a patent for a method of preparing an itraconazole formulation. This method involves dissolving a mixture of itraconazole and L-ascorbic acid in a mixed solvent of dichloromethane and methanol. The process includes adding hydroxypropyl methylcellulose and pluronic F-127, followed by the introduction of dichloromethane into the mixed solvent to create a raw material solution. The solution is then subjected to supercritical fluid crystallization, where carbon dioxide is fed into a crystallization autoclave. The solution is sprayed into the autoclave, resulting in the separation of composite particles, which are collected and encapsulated to produce an itraconazole formulation with decreased particle size and increased bioavailability.

Career Highlights

Throughout his career, Jiansheng Han has worked with prominent companies in the pharmaceutical industry. He has been associated with Changzhou Pharmaceutical Factory Co., Ltd. and Crystec Ltd. His experience in these organizations has contributed to his expertise in pharmaceutical innovations.

Collaborations

Jiansheng Han has collaborated with notable colleagues, including Xuezhi Yin and Linda Sharon Daintree. These collaborations have likely enriched his research and development efforts in the field of pharmaceutical formulations.

Conclusion

Jiansheng Han's contributions to the pharmaceutical industry, particularly through his innovative methods for preparing itraconazole formulations, highlight his role as a significant inventor. His work not only advances pharmaceutical science but also enhances the effectiveness of treatments for patients.