Location History:
- Suzhou, CN (2016 - 2019)
- Jiangsu, CN (2019)
Company Filing History:
15 out of 15 
1 out of 1 
1 out of 1 Years Active: 2016-2019
Title: Xuenong Xu: Pioneer in Pharmaceutical Innovations
Introduction
Xuenong Xu is a distinguished inventor based in Suzhou, China, known for his significant contributions to the field of pharmaceuticals. With a remarkable portfolio of 17 patents, Xu has focused on developing innovative preparation methods for various pharmaceutical compounds, enhancing production efficiency and sustainability.
Latest Patents
Among Xuenong Xu's latest patents is a groundbreaking preparation method for cobimetinib, also known as XL518 or GDC-0973. The disclosed process begins with (2S)-2-piperidinecarboxylic acid as a raw material, involving acyl cyanation, hydrolysis, esterification, and Boc protection to create an intermediate compound. Subsequent reactions, including addition, reduction, and cyclization, lead to the final product, cobimetinib. This method boasts advantages such as the use of accessible raw materials, simplicity in techniques, high economic viability, and eco-friendliness, making it optimal for industrial production.
Xu has also developed an innovative method for preparing nilotinib intermediates, specifically 3-(4-methyl-1H-imidazol-1-yl)-5-trifluoromethyl phenylamine. The process utilizes trifluorotoluene as the initial material and involves nitration, bromization, condensation, and reduction steps. This novel method yields a relatively high output and features an efficient production process with minimal side reactions, further propelling the development of economically viable bulk drug technologies.
Career Highlights
Throughout his career, Xuenong Xu has held prominent positions in the pharmaceutical sector, particularly working with reputable firms such as Suzhou Miracpharma Technology Co., Ltd. and Suzhou Lixin Pharmaceutical Co., Ltd. His expertise and innovative approaches to drug preparation have led to significant advancements in pharmaceutical manufacturing.
Collaborations
Xuenong Xu has collaborated with esteemed colleagues in the industry, including Deli Zeng and Liang Shu. Their combined expertise and teamwork have contributed to the successful development of Xu's innovative patent applications, enhancing the capabilities and reputations of their associated companies.
Conclusion
Xuenong Xu's commitment to innovation and excellence in pharmaceutical research is evident through his extensive portfolio of patents and collaborative efforts within the industry. His contributions not only advance the field but also demonstrate the potential for sustainable and efficient drug production methods. As he continues to explore new avenues in pharmaceuticals, Xu remains a prominent figure in the landscape of invention and innovation.