The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 27, 2018
Filed:
Apr. 12, 2018
Applicant:
Suzhou Miracpharma Technology Co., Ltd., Suzhou, CN;
Inventor:
Xuenong Xu, Suzhou, CN;
Assignee:
SUZHOU MIRACPHARMA TECHNOLOGY CO., LTD., Suzhou, CN;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 239/48 (2006.01); C07D 403/12 (2006.01);
U.S. Cl.
CPC ...
C07D 403/12 (2013.01); C07D 239/48 (2013.01);
Abstract
Disclosed is a method for preparing Rociletinib. 2-[[4-(4-acetyl-1-piperazinyl)-2-methoxyphenyl]amino]-5 -(trifluoromethyl)-pyrimidin-4-one is obtained by means of a condensation reaction of easily obtainable raw materials 5-(trifluoromethyl)uracil and 4-(4-acetylpiperazin-1-yl)-2-methoxyaniline, an intermediate is subjected to a halogenation reaction and an amination reaction to produce Rociletinib (I). The preparation method has easily obtainable raw materials, a simple process, is economic and environmentally friendly, and is suitable for industrial production.