The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 27, 2019
Filed:
Jul. 07, 2016
Suzhou Lixin Pharmaceutical Co., Ltd, Suzhou, CN;
Xuenong Xu, Suzhou, CN;
Xuenong Xu, Suzhou, CN;
Deli Zeng, Suzhou, CN;
Liang Shu, Suzhou, CN;
Qing Zhang, Suzhou, CN;
Zhijian Bao, Suzhou, CN;
Jia Xue, Suzhou, CN;
Jian Su, Suzhou, CN;
Zhe Wang, Suzhou, CN;
Wenjie Zhou, Suzhou, CN;
Lingling Xie, Suzhou, CN;
SUZHOU LIXIN PHARMACEUTICAL CO., LTD., Suzhou, CN;
Other;
Abstract
Disclosed in the present invention is a method for preparing nilotinib intermediate 3-(4-methyl-1H-imidazol-1-yl)-5trifluoromethyl phenylamine (I). The method comprises the following steps: taking trifluorotoluene as an initial material, and preparing the nilotinib intermediate (I) by nitration, bromization, condensation and reduction successively Compared with the prior art, the preparation method has the following advantages: a relatively high yield, the raw materials are easily obtained, a concise process and few side reactions, and is adapted to industrial production, so the development of an economic technology of the bulk drug is promoted.