This inventor holds 10 USPTO granted patents and 8 published patent applications, plus 3 CIPO patents and 6 EPO patents. Top assignees: Meiragtx UK Ii Limited, Meiragtx Gene Regulation Limited. Active years: 2019-2026.
Location History:
- Oyster Bay, NY (US) (2022)
- Cold Spring Harbor, NY (US) (2019 - 2023)
Company Filing History:
Years Active: 2019-2026
Title: Xuecui Guo: Innovator in Gene Regulation
Introduction
Xuecui Guo is a prominent inventor based in Cold Spring Harbor, NY (US). He has made significant contributions to the field of gene regulation, holding a total of 10 patents. His innovative work focuses on the modulation of gene expression through advanced techniques involving aptamers and ribozymes.
Latest Patents
One of Guo's latest patents is titled "Regulation of gene expression by aptamer-mediated modulation of alternative splicing." This invention provides a platform and methods for regulating the expression of a target gene using exposure to an aptamer ligand, such as a small molecule. The platform features a polynucleotide gene regulation cassette that is integrated into the target gene, including a synthetic riboswitch positioned within a 5' intron-alternative exon-3′ intron. The riboswitch consists of an effector region and a sensor region, allowing for the alternative exon to be spliced into the target gene mRNA when the ligand is absent, thus preventing expression. Conversely, when the ligand is present, the alternative exon is not spliced, enabling expression of the target gene.
Another notable patent is "Regulation of gene expression via aptamer-mediated control of self-cleaving ribozymes." This invention provides polynucleotide constructs for regulating gene expression through aptamer-based modulation of self-cleaving ribozymes. It includes methods for using these constructs to control gene expression in response to the presence or absence of a ligand that binds the aptamer. The invention also outlines methods for creating riboswitches that can either decrease or increase target gene expression based on the aptamer ligand.
Career Highlights
Throughout his career, Xuecui Guo has worked with several notable companies, including MeiraGTx UK II Limited and MeiraGTx Gene Regulation Limited. His work in these organizations has furthered the development of innovative gene regulation technologies.
Collaborations
Guo has collaborated with esteemed colleagues such as Olivier F. Danos and Michael J. Volles, contributing to advancements in the field of gene regulation.
Conclusion
Xuecui Guo's contributions to gene regulation through his innovative patents and collaborations highlight his significant role in advancing biotechnology. His work continues to influence the field and pave the way for future innovations in