The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 29, 2023
Filed:
Mar. 02, 2018
Applicant:
Meiragtx Uk Ii Limited, London, GB;
Inventor:
Xuecui Guo, Cold Spring Harbor, NY (US);
Assignee:
MEIRAGTX UK II LIMITED, London, GB;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/115 (2010.01); C12N 15/11 (2006.01); C12N 15/67 (2006.01);
U.S. Cl.
CPC ...
C12N 15/115 (2013.01); C12N 15/111 (2013.01); C12N 15/67 (2013.01); C12N 2310/126 (2013.01); C12N 2310/16 (2013.01); C12N 2310/3519 (2013.01); C12N 2310/531 (2013.01);
Abstract
The present disclosure provides polynucleotide constructs for the modulation of target gene expression by aptamer-mediated ribonuclease cleavage of the target gene RNA and methods of using the constructs to modulate gene expression in response to the presence or absence of a ligand that binds the aptamer. The polynucleotide constructs contains a ribonuclease substrate sequence (e.g., an RNase P substrate) and a riboswitch comprising an effector region and an aptamer such that when the aptamer binds a ligand, target gene expression occurs.