Company Filing History:
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1 out of 832,812 Years Active: 2003-2006
Title: Xu-Shan Wang: Innovator in Gene Therapy
Introduction
Xu-Shan Wang is a notable inventor based in Carmel, IN (US). He has made significant contributions to the field of gene therapy, particularly through his innovative research and patented inventions. With a total of 2 patents, his work has advanced our understanding of viral mechanisms and gene expression.
Latest Patents
One of Xu-Shan Wang's latest patents is titled "Role of tyrosine phosphorylation of a cellular protein in adeno-associated virus 2-mediated transgene expression." This invention identifies a protein known as the D-sequence-binding protein (D-BP), which is phosphorylated at tyrosine residues. The D-BP blocks AAV-mediated transgene expression in infected cells by inhibiting the leading strand viral DNA synthesis. The patent further demonstrates that D-BP is phosphorylated by EGF-R protein tyrosine kinase. Additionally, methods of increasing transcription and promoting replication of transgenes are disclosed in this patent. Another significant patent is related to "AAV vectors," which involves a recombinant adenovirus vector comprising two inverted terminal repeats (ITRs) that include a D-sequence with specific native nucleotides and potential deletions or substitutions.
Career Highlights
Throughout his career, Xu-Shan Wang has worked with various research institutions, contributing to advancements in biotechnology and gene therapy. His innovative approaches have led to breakthroughs in understanding viral interactions and gene expression mechanisms.
Collaborations
Xu-Shan Wang has collaborated with esteemed colleagues such as Arun Srivastava and Selvarangan Ponnazhagan. These collaborations have fostered a productive research environment, leading to significant advancements in their respective fields.
Conclusion
Xu-Shan Wang's contributions to gene therapy through his patents and collaborations highlight his role as an influential inventor. His work continues to impact the scientific community and advance the field of biotechnology.