The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 30, 2006
Filed:
Sep. 01, 1998
Arun Srivastava, Indianapolis, IN (US);
Keyun Qing, Indianapolis, IN (US);
Xu-shan Wang, Carmel, IN (US);
Selvarangan Ponnazhagan, Birmingham, AL (US);
Anil Bajpai, Indianapolis, IN (US);
Arun Srivastava, Indianapolis, IN (US);
Keyun Qing, Indianapolis, IN (US);
Xu-Shan Wang, Carmel, IN (US);
Selvarangan Ponnazhagan, Birmingham, AL (US);
Anil Bajpai, Indianapolis, IN (US);
Advanced Research & Technology Institute, Bloomington, IN (US);
Abstract
The present invention identifies a protein, designated the D-sequence-binding protein (D-BP), is phosphorylated at tyrosine residues and blocks AAV-mediated transgene expression in infected cells by inhibiting the leading strand viral DNA synthesis. More particularly, the present invention demonstrates that D-BP is phosphorylated by EGF-R protein tyrosine kinase. Methods of increasing transcription and promoting replication of transgenes exploiting this information are disclosed herein.