Company Filing History:
2 out of 366 
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1 out of 832,812 Years Active: 1993-2006
Title: Innovations and Contributions of Inventor Arun Srivastava
Introduction
Arun Srivastava is a notable inventor based in Indianapolis, IN (US). He has made significant contributions to the field of biotechnology, particularly in the area of gene therapy and viral vectors. With a total of 4 patents to his name, his work has had a profound impact on the understanding and application of adeno-associated viruses in gene expression.
Latest Patents
One of Arun Srivastava's latest patents is titled "Role of tyrosine phosphorylation of a cellular protein in adeno-associated virus 2-mediated transgene expression." This invention identifies a protein known as the D-sequence-binding protein (D-BP), which is phosphorylated at tyrosine residues. The D-BP blocks AAV-mediated transgene expression in infected cells by inhibiting the leading strand viral DNA synthesis. The invention also demonstrates that D-BP is phosphorylated by EGF-R protein tyrosine kinase. Furthermore, methods of increasing transcription and promoting replication of transgenes by exploiting this information are disclosed in this patent. Another significant patent is related to "AAV vectors," which is directed to a recombinant adenovirus vector comprising two inverted terminal repeats (ITRs), each of which includes a D-sequence with specific native nucleotides and potential deletions or substitutions.
Career Highlights
Throughout his career, Arun Srivastava has worked with various organizations, including Research Corporation Technologies, Inc. His expertise in biotechnology and gene therapy has positioned him as a key figure in the development of innovative solutions in this field.
Collaborations
Arun has collaborated with notable professionals in his field, including Selvarangan Ponnazhagan and Xu-Shan Wang. These collaborations have further enhanced his research and contributions to biotechnology.
Conclusion
Arun Srivastava's work exemplifies the innovative spirit of modern inventors. His patents and collaborations have significantly advanced the understanding of gene therapy and viral vectors, making him a prominent figure in the field.