Xinhua Ji

Title: Xinhua Ji: Innovator in Antibacterial Agents

Introduction

Xinhua Ji is a prominent inventor based in Frederick, MD (US), known for his significant contributions to the field of antibacterial agents. With a total of 6 patents, Ji has made remarkable strides in developing novel compounds that target essential processes in bacterial biosynthesis.

Latest Patents

Among his latest patents, Ji has developed HPPK inhibitors that are useful as antibacterial agents. The first patent discloses linked purine pterin compounds of Formula I, which serve as novel inhibitors of HPPK, a kinase crucial for folic acid biosynthesis. These inhibitors exhibit high affinity and specificity for HPPK. Additionally, pharmaceutical compositions containing these HPPK inhibitors and methods for treating bacterial infections using these compounds are also provided. Another patent focuses on linked purine pterin HPPK inhibitors, detailing compounds and their pharmaceutically acceptable salts of general Formula I. The methods described guide the development of additional novel antibacterial agents.

Career Highlights

Xinhua Ji is affiliated with the National Institutes of Health, a component of the US Department of Health & Human Services. His work at this esteemed institution has allowed him to focus on innovative research aimed at combating bacterial infections through novel therapeutic approaches.

Collaborations

Ji has collaborated with notable colleagues, including Larry K Keefer and Genbin Shi, enhancing the scope and impact of his research in the field of antibacterial agents.

Conclusion

Xinhua Ji's innovative work in developing HPPK inhibitors showcases his commitment to advancing medical science and addressing critical health challenges. His contributions are paving the way for new treatments in the fight against bacterial infections.