The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 27, 2015
Filed:
Oct. 18, 2012
Applicant:
The United States of America, As Represented BY the Secretary, Department of Health and Human Services, Washington, DC (US);
Inventors:
Anna E. Maciag, Frederick, MD (US);
Larry K. Keefer, Bethesda, MD (US);
Joseph E. Saavedra, Thurmont, MD (US);
Xinhua Ji, Frederick, MD (US);
Vandana Kumari, Frederick, MD (US);
Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 403/10 (2006.01); A61K 31/655 (2006.01); A61K 45/06 (2006.01); A61K 31/69 (2006.01); A61K 31/704 (2006.01); C07D 237/30 (2006.01); C07D 295/28 (2006.01); C07C 291/02 (2006.01); C07D 237/32 (2006.01);
U.S. Cl.
CPC ...
A61K 31/655 (2013.01); A61K 31/69 (2013.01); A61K 31/704 (2013.01); A61K 45/06 (2013.01); C07C 291/02 (2013.01); C07D 237/30 (2013.01); C07D 237/32 (2013.01); C07D 295/28 (2013.01); C07D 403/10 (2013.01);
Abstract
Disclosed are hybrid compounds that release both nitric oxide and a moiety that inhibits poly (ADP-ribose) polymerase (PARP), e.g., a compound or a pharmaceutically acceptable salt thereof of formula (I), wherein Rand m-p are as described herein. Also disclosed are pharmaceutical compositions and methods of use including treating cancer and enhancing the chemotherapeutic treatment of chemotherapeutic agents and high energy radiation.