The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 26, 2003
Filed:
May. 03, 1999
Joseph E. Saavedra, Thurmount, MD (US);
Larry K. Keefer, Bethesda, MD (US);
Aloka Srinivasan, Wilmington, DE (US);
William G. Rice, Frederick, MD (US);
Xinhua Ji, Gaithersburg, MD (US);
Christian Bogdan, Wasserturmstrasse, DE;
Abstract
Diazeniumdiolates, wherein the N position is substituted by an inorganic or organic moiety and the O -oxygen is bound to a substituted or unsubstituted aromatic group, are provided. Also provided are O -glycosylated 1-substituted diazen-1-ium-1,2-diolates (O -glycosylated diazeniumdiolates) and O -substituted 1-[(2-carboxylato)pyrrolidin-1-yl]diazen-1-ium-1,2-diolates (1-[(2-carboxylato)pyrrolidin-1-yl]diazeniumdiolates). The O -aryl diazeniumdiolates are stable with respect to the hydrolytic generation of nitric oxide in neutral to acidic solutions and generate nitric oxide in basic or nucleophilic environments or microenvironments. Also provided are compositions, including pharmaceutical compositions, comprising such compounds and methods of using such compounds.