Xiaotian Zhong

Title: Innovations of Xiaotian Zhong in Antibody Production

Introduction

Xiaotian Zhong is a prominent inventor based in Wayland, MA (US), known for his significant contributions to the field of therapeutic protein conjugation. With a total of 7 patents, he has made remarkable advancements in optimizing antibody production processes.

Latest Patents

Zhong's latest patents focus on large-scale production processes for capped and uncapped antibody cysteines. One of his notable inventions involves optimizing the production of selectively capped and uncapped cysteines on antibodies by manipulating cell growth conditions. This includes the deliberate depletion of cysteine and/or cystine in the cell culture process through media components, batch duration, or cell density. His work aims to achieve efficient production of proteins, including antibody-drug conjugates (ADCs). Another significant patent details the conjugation of a TNB-capped cysteine-containing protein by reacting it with a reducing agent. This process detaches the TNB-capping moieties from the protein without significantly reducing antibody inter-chain sulfur bonds, allowing for the conjugation of reduced sulfur bonds on the protein to a payload through a reactive linking moiety.

Career Highlights

Throughout his career, Xiaotian Zhong has worked with notable companies such as Wyeth and Pfizer Corporation. His experience in these organizations has contributed to his expertise in the field of antibody production and therapeutic applications.

Collaborations

Zhong has collaborated with esteemed colleagues, including Ronald William Kriz and Amarnauth Shastrie Prashad. These partnerships have further enhanced his research and development efforts in the biotechnology sector.

Conclusion

Xiaotian Zhong's innovative work in antibody production and therapeutic protein conjugation has positioned him as a key figure in the field. His patents and collaborations reflect his commitment to advancing medical science through innovative solutions.