The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 22, 2024
Filed:
Feb. 01, 2018
Pfizer Inc., New York, NY (US);
Kaushik Dutta, River Edge, NJ (US);
Jose Manuel Gomes, Kingston, NH (US);
Frank W. Kotch, Pearl River, NY (US);
Vimalkumar B. Patel, Jersey City, NJ (US);
Amarnauth Shastrie Prashad, New City, NY (US);
Renee L. Procopio-Melino, Andover, MA (US);
Xiaotian Zhong, Wayland, MA (US);
PFIZER INC., New York, NY (US);
Abstract
Optimizing production of selectively capped, and uncapped, cysteines on antibodies by manipulation of cell growth conditions including the deliberate depletion of cysteine and/or cystine in the cell culture process by way of media components, batch duration, or cell density to achieve efficient production of proteins including antibody-drug-conjugates (ADCs).; conjugating a TNB-capped cysteine-containing protein by reacting it with a reducing agent capable of detaching the TNB-capping moieties from the protein without significantly reducing antibody inter-chain sulfur bonds, and conjugating reduced sulfur bonds on the protein to a payload through a reactive linking moiety.