Location History:
- Gaithersburg, MD (US) (2002 - 2008)
- North Potomac, MD (US) (2001 - 2013)
Company Filing History:
Years Active: 2001-2013
Title: Wu-Bo Li: Innovator in Nucleic Acid Synthesis and Viral Intervention
Introduction
Wu-Bo Li is a prominent inventor based in Gaithersburg, MD (US), known for his significant contributions to the fields of nucleic acid synthesis and viral intervention. With a total of 6 patents, his work has advanced the understanding and treatment of viral infections, particularly HIV.
Latest Patents
One of Wu-Bo Li's latest patents focuses on methods of inhibiting HIV infectivity. This innovative approach utilizes a Gene Search Vector, which can be either lentivirus or MMLV-based, to identify host genes and proteins that serve as potential therapeutic targets. The Random Homozygous Gene Perturbation (RUGP) technique he developed allows for rapid verification and identification of host targets for various viral infections, significantly reducing the time required for target identification from months to weeks or less. Specific targets such as PTCH1, Robo1, and Nedd4 are explored in detail within this patent.
Another notable patent by Wu-Bo Li involves methods for producing polypeptides through enhanced synthesis of encoding nucleic acid molecules. This invention provides compositions and methods aimed at improving the synthesis of GC-rich nucleic acid molecules. The compositions include nitrogen-containing organic compounds and are designed to enhance high-fidelity synthesis through various methods, including PCR and reverse transcription. The invention also encompasses kits for synthesizing and amplifying nucleic acid molecules.
Career Highlights
Throughout his career, Wu-Bo Li has worked with notable companies such as Invitrogen Corporation and Functional Genetics, Inc. His expertise in the field has led to significant advancements in the synthesis of nucleic acids and the development of therapeutic interventions for viral infections.
Collaborations
Wu-Bo Li has collaborated with esteemed colleagues, including Joel A Jessee and David M Schuster, contributing to the advancement of research in his areas of expertise.
Conclusion
Wu-Bo Li's innovative work in nucleic acid synthesis and viral intervention has made a lasting impact on the scientific community. His patents reflect a commitment to advancing therapeutic strategies for combating viral infections, particularly HIV.