The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 17, 2013
Filed:
Jan. 06, 2010
Michael S. Kinch, Laytonsville, MD (US);
Michael Goldblatt, McLean, VA (US);
Wu-bo LI, North Potomac, MD (US);
Douty Bamba, Randallstown, MD (US);
Shaojing Chang, Rockville, MD (US);
Huosheng Chen, Germantown, MD (US);
Zenbework Fesseha, Columbia, MD (US);
Manu Kohli, Dunn Loring, VA (US);
Hanwen Mao, Annandale, VA (US);
Heather Thi Thu Ung-medoff, Gaithersburg, MD (US);
KE Weng, Gaithersburg, MD (US);
Michael S. Kinch, Laytonsville, MD (US);
Michael Goldblatt, McLean, VA (US);
Wu-Bo Li, North Potomac, MD (US);
Douty Bamba, Randallstown, MD (US);
Shaojing Chang, Rockville, MD (US);
Huosheng Chen, Germantown, MD (US);
Zenbework Fesseha, Columbia, MD (US);
Manu Kohli, Dunn Loring, VA (US);
Hanwen Mao, Annandale, VA (US);
Heather Thi Thu Ung-Medoff, Gaithersburg, MD (US);
Ke Weng, Gaithersburg, MD (US);
Functional Genetics, Inc., Gaithersburg, MD (US);
Abstract
A method for identifying host genes and encoded proteins for potential targets for therapeutic intervention employs a Gene Search Vector that is either lentivirus or MMLV-based, and can be used to interrogate an entire cell genome without prior knowledge of the genomic sequence. This Random Homozygous Gene Perturbation (RUGP) technique is rapidly verifiable and is used to identify potential host targets for intervention for influenza, HIV and other viral infections. Using Thermal Assymetric Interlaced (TAIL)-PCR, the period for identification of promising targets is reduced from months to weeks or less. Specific targets including PTCH1, Robo1 and Nedd4 are reviewed in detail.