Shaojing Chang

Title: Innovations of Shaojing Chang in HIV Research

Introduction

Shaojing Chang is a notable inventor based in Rockville, MD, who has made significant contributions to the field of medical research, particularly in the area of HIV infectivity. His innovative approaches have the potential to transform therapeutic interventions for viral infections.

Latest Patents

Chang holds a patent for "Methods of inhibiting HIV infectivity." This patent describes a method for identifying host genes and encoded proteins that serve as potential targets for therapeutic intervention. The technique employs a Gene Search Vector, which can be either lentivirus or MMLV-based, allowing researchers to interrogate an entire cell genome without prior knowledge of the genomic sequence. This Random Homozygous Gene Perturbation (RUGP) technique is rapidly verifiable and is instrumental in identifying potential host targets for intervention against influenza, HIV, and other viral infections. Notably, the use of Thermal Asymmetric Interlaced (TAIL)-PCR significantly reduces the period for identifying promising targets from months to weeks or less. Specific targets, including PTCH1, Robo1, and Nedd4, are reviewed in detail within the patent.

Career Highlights

Chang is associated with Functional Genetics, Inc., where he continues to advance his research and innovations. His work is characterized by a commitment to improving therapeutic strategies for viral infections, showcasing his dedication to public health.

Collaborations

Chang has collaborated with notable colleagues, including Michael Scott Kinch and Michael Goldblatt, who share his passion for advancing medical research and innovation.

Conclusion

Shaojing Chang's contributions to HIV research through his innovative patent demonstrate his significant role in the scientific community. His work not only enhances our understanding of viral infections but also paves the way for future therapeutic advancements.