Location History:
- Hohengendern, DE (2006)
- Hohengandem, DE (2007)
- Hohengandern, DE (2006 - 2020)
Company Filing History:
28 out of 1,288 
14 out of 8,369 
14 out of 1,551 
Years Active: 2006-2020
Title: The Innovative Contributions of Winfried Lendeckel in RNA Interference
Introduction
Winfried Lendeckel, based in Hohengandern, Germany, has made significant contributions to the field of molecular biology, particularly in the area of RNA interference (RNAi). With an impressive portfolio of 28 patents, his work has advanced our understanding of gene silencing mechanisms and the use of small RNA molecules in various organisms.
Latest Patents
One of Lendeckel's most notable patents focuses on RNA interference mediating small RNA molecules. This work illustrates how double-stranded RNA (dsRNA) induces sequence-specific post-transcriptional gene silencing through RNAi. Lendeckel's research demonstrates that 19-23 nucleotide short RNA fragments are critical for mediating this process. His findings indicate that short interfering RNAs (siRNAs) are generated by an RNase III-like processing reaction from long dsRNA, leading to efficient target RNA cleavage when chemically synthesized siRNA duplexes with overhanging 3' ends are utilized. Furthermore, he provides compelling evidence that the direction of dsRNA processing is crucial in determining whether sense or antisense target RNA can be cleaved by the resulting siRNA ribonucleoprotein (siRNP) complex.
Career Highlights
Lendeckel's career reflects a dedication to advancing scientific knowledge in molecular genetics. He has been associated with prestigious institutions, contributing to significant advancements in RNA research. His work has not only expanded the scientific community's understanding of RNA mechanisms but also paved the way for potential therapeutic applications.
Collaborations
Throughout his career, Lendeckel has worked alongside notable scientists, including Sayda Mahgoub Elbashir and Thomas Tuschl. These collaborations have further enriched his research and fostered a vibrant exchange of ideas within the scientific community. Additionally, he has worked with renowned organizations such as the Max Planck Society for the Advancement of Science and the Massachusetts Institute of Technology, enhancing his research's impact and reach.
Conclusion
Winfried Lendeckel’s innovative work in the field of RNAi exemplifies the critical role that inventors play in scientific advancements. His patents and collaborations continue to influence molecular biology, offering valuable insights into gene regulation and treatment strategies. As research in this field evolves, Lendeckel’s contributions will undoubtedly remain influential.
Inventor’s Patent Attorneys refers to legal professionals with specialized expertise in representing inventors throughout the patent process. These attorneys assist inventors in navigating the complexities of patent law, including filing patent applications, conducting patent searches, and protecting intellectual property rights. They play a crucial role in helping inventors secure patents for their innovative creations.