Company Filing History:
2 out of 29 
2 out of 3 Years Active: 2013-2015
Title: Innovations of Vijayavitthal Thippannachar Mathad
Introduction
Vijayavitthal Thippannachar Mathad is a notable inventor based in Maharashtra, India. He has made significant contributions to the field of pharmaceuticals, holding three patents that showcase his innovative approaches to drug preparation.
Latest Patents
Mathad's latest patents include a process for the preparation of bosentan, which involves creating a novel ammonium salt of bosentan. This process allows for the production of the salt in either crystalline or amorphous forms. The method entails reacting 4,6-dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine with 4-tert-butylbenzenesulfonamide in the presence of a solvent and a base. Ethylene glycol is then added to the reaction mass to isolate the ammonium salt of bosentan. This ammonium salt can be converted into bosentan and further into bosentan monohydrate, which is substantially free from dimer and 6-hydroxy impurities. Another significant patent involves a method for the preparation of cinacalcet and its intermediates. This method includes treating (R)-1-naphthyl ethylamine with an aromatic aldehyde to form a derivative, which is subsequently treated with 1-(3-halopropyl)-3-(trifluoromethyl)benzene to obtain an iminium salt, followed by hydrolysis to yield cinacalcet free base.
Career Highlights
Throughout his career, Mathad has worked with reputable companies in the pharmaceutical industry, including Amneal Pharmaceuticals and Megafine Pharma. His experience in these organizations has contributed to his expertise in drug formulation and development.
Collaborations
Mathad has collaborated with notable colleagues such as Navnath Chintaman Niphade and Gorakshanath Balasaheb Shinde. These collaborations have likely enhanced his research and development efforts in the pharmaceutical sector.
Conclusion
Vijayavitthal Thippannachar Mathad's innovative work in drug preparation has led to significant advancements in the pharmaceutical field. His patents reflect a commitment to improving drug formulations and addressing impurities, showcasing his valuable contributions to the industry.