The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 05, 2013
Filed:
Sep. 06, 2011
Vijayavitthal Thippannachar Mathad, Maharashtra, IN;
Navnath Chintaman Niphade, Maharashtra, IN;
Gorakshanath Balasaheb Shinde, Maharashtra, IN;
Sharad Subhash Ippar, Maharashtra, IN;
Shrikant Prataprao Deshmukh, Maharashta, IN;
Raghavendra Kumar Panchangam, Maharashtra, IN;
Vijayavitthal Thippannachar Mathad, Maharashtra, IN;
Navnath Chintaman Niphade, Maharashtra, IN;
Gorakshanath Balasaheb Shinde, Maharashtra, IN;
Sharad Subhash Ippar, Maharashtra, IN;
Shrikant Prataprao Deshmukh, Maharashta, IN;
Raghavendra Kumar Panchangam, Maharashtra, IN;
Amneal Pharmaceuticals, LLC, Bridgewater, NJ (US);
Megafine Pharma (P) Ltd., Maharashtra, IN;
Abstract
A method for the preparation of Cinacalcet is disclosed comprising treating (R)-1-naphthyl ethylamine with an aromatic aldehyde to form (1R)-1-(2-naphthyl)-N-(aryl methylene)ethanamine derivative of Formula (IV), which is further treated with 1-(3-halopropyl)-3-(trifluoromethyl)benzene of Formula (V) to obtain an iminium salt of Formula (VI), followed by hydrolysis to obtain Cinacalcet free base.