The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 22, 2015
Filed:
Mar. 28, 2011
Vijayavitthal Thippannachar Mathad, Maharashtra, IN;
Navnath Chintaman Niphade, Maharashtra, IN;
Kunal Madhav Jagtap, Maharashtra, IN;
Chandrashekar Trimbak Gaikwad, Maharashtra, IN;
Vijayavitthal Thippannachar Mathad, Maharashtra, IN;
Navnath Chintaman Niphade, Maharashtra, IN;
Kunal Madhav Jagtap, Maharashtra, IN;
Chandrashekar Trimbak Gaikwad, Maharashtra, IN;
Megafine Pharma(P) Ltd., Mumbai, Maharashtra, IN;
Abstract
A novel ammonium salt of Bosentan of formula (VIII); has been disclosed. The salt may be either crystalline or amorphous or mixture of Crystalline and amorphous form. A novel single pot process for the preparations of ammonium salt of Bosentan has been disclosed. The process comprises reacting the 4,6-dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine with 4-tert-butylbenzenesulfonamide in the presence of solvent and a base; adding ethylene glycol to the reaction mass and isolating the ammonium salt of Bosentan. The ammonium salt of Bosentan is converted into Bosentan and further into Bosentan Monohydrate which are substantially free from dimer impurity and 6-hydroxy impurity.