Company Filing History:
Years Active: 2013-2019
Title: Vesa Nevalainen: Innovator in Cholesterol Modulation and Fatty Acid Synthesis Inhibition
Introduction
Vesa Nevalainen is a notable inventor based in Weymouth, MA (US), recognized for his contributions to the fields of biochemistry and pharmacology. With a total of 4 patents, he has made significant strides in developing innovative solutions for health-related challenges, particularly in managing cholesterol levels and fatty acid synthesis.
Latest Patents
One of Nevalainen's latest patents focuses on proprotein convertase subtilisin kexin type 9 (PCSK9) allosteric binding ligands. This invention aims to modulate serum low-density lipoprotein (LDL) levels, which is crucial in addressing hypercholesterolemia. The invention provides compositions and methods to alter the conformation of the PCSK9 protein using synthetic ligands and/or synthetic ligand derivative sequences of 3-8 amino acids, ranging between 350-2,000 Da. By changing the conformation of PCSK9, the interaction between PCSK9 and the endogenous low-density lipoprotein receptor can be affected, leading to either reduced or increased levels of circulating LDL-cholesterol. This is particularly important as high LDL-cholesterol levels are associated with an increased risk of heart disease, while low levels may pose problems in conditions such as liver dysfunction.
Another significant patent involves tetrazolones as inhibitors of fatty acid synthase. This patent presents tetrazolone FASN inhibitors and their pharmaceutical compositions, which can be utilized for treating various disorders, including hyperproliferative disorders, inflammatory disorders, obesity-related disorders, and microbial infections.
Career Highlights
Throughout his career, Vesa Nevalainen has worked with several prominent companies, including Infinity Pharmaceuticals, Inc. and Srx Cardio, LLC. His work in these organizations has allowed him to develop and refine his innovative ideas, contributing to advancements in medical science.
Collaborations
Nevalainen has collaborated with various professionals in his field, including Adilah Bahadoor and Alfredo C. Castro. These collaborations have likely enriched his research and development efforts, fostering a collaborative environment for innovation.
Conclusion
Vesa Nevalainen's contributions to the fields of cholesterol modulation and fatty acid synthesis inhibition highlight his role as a significant inventor. His innovative patents and collaborations