The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 14, 2019
Filed:
Aug. 13, 2015
Srx Cardio, Llc, Pittsford, NY (US);
Michael M. Muehlemann, Liverpool, NY (US);
Thomas E. Barta, Carrboro, NC (US);
Kyle D. Monroe, Pittsford, NY (US);
Jonathan William Bourne, Fairport, NY (US);
Margaret Thompson Reece, Fayetteville, NY (US);
Vesa Nevalainen, Weymouth, MA (US);
Eric T. Baldwin, Upper Holland, PA (US);
SRX Cardio, LLC, Pittsford, NY (US);
Abstract
This invention is related to the field of hypercholesterolemia. In particular, the invention provides compositions and methods to modulate circulating levels of low density lipoproteins by altering the conformation of the protein PCSK9 using synthetic ligands and/or synthetic ligand derivative sequences of 3-8 amino acids ranging between 350-2,000 Da. Altering the conformation of PCSK9 affects the interaction between PCSK9 and an endogenous low density lipoprotein receptor, and can lead to reduced or increased levels of circulating LDL-cholesterol. High LDL-cholesterol levels are associated with increased risk for heart disease. Low LDL-cholesterol levels may be problematic in other conditions, such as liver dysfunction; thus, there is also utility for ligands which can raise LDL levels.