Company Filing History:
Years Active: 2015
Title: **Innovative Contributions of Upasana Singh in Anti-Tuberculous Research**
Introduction
Upasana Singh, an inventive mind based in Maharashtra, India, has made significant strides in the field of anti-tuberculous research. With a keen focus on extracting bioactive compounds from plants, Singh showcases the potential of natural resources in combating infectious diseases.
Latest Patents
Singh holds one notable patent detailing the active fractions exhibiting anti-tuberculous activity derived from the Sterculiaceae family of plants. The patent highlights how methanol extracts from the aerial parts of these plants demonstrated activity against Mycobacterium tuberculosis glutamine synthetase (MtbGS) during primary screening. Through subsequent fractionation with organic solvents, two specific fractions, D and K, showed promising inhibitory activity, accomplishing 74% and 44% inhibition of glutamine synthetase at concentrations of 7.5 mg/ml, respectively. The determined IC value for fraction K was found to be 4.5 mg/ml, indicating its robust potential against the purified enzyme. Notably, fraction K exhibited an IC value for BCG of 1.56 µg/ml while presenting no significant effects on the proliferation of the HL-60 cell line at 10 times the MIC levels, suggesting a favorable safety profile for these compounds.
Career Highlights
Upasana Singh is associated with the Council of Scientific & Industrial Research, where she actively contributes to research and innovation in the field of pharmaceuticals and natural products. Her work exemplifies the integration of scientific research with practical applications in healthcare.
Collaborations
In her journey of innovation, Singh has collaborated with esteemed colleagues such as Dhiman Sarkar and Swati Pramod Joshi. Their collective efforts underscore the importance of teamwork in advancing scientific discoveries and developing effective medicinal therapies.
Conclusion
Upasana Singh's contributions to the realm of anti-tuberculous activity represent a critical intersection of traditional knowledge and modern science. Through her patented research, she paves the way for new potential treatments, emphasizing the importance of exploring and utilizing natural resources in combating infectious diseases. Her ongoing work exemplifies the spirit of innovation crucial for advancements in public health.