The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 12, 2015
Filed:
Sep. 21, 2012
Council of Scientific & Industrial Research, New Delhi, IN;
Dhiman Sarkar, Maharashtra, IN;
Swati Pramod Joshi, Maharashtra, IN;
Upasana Singh, Maharashtra, IN;
Ketaki Dilip Shurpali, Maharashtra, IN;
Roshan Rajan Kulkarni, Maharashtra, IN;
Council of Scientific & Industrial Research, New Delhi, IN;
Abstract
Active fractions exhibiting anti-tuberculous activity from the plant(family—Sterculiaceae) are described. Methanol extracts of the aerial part ofexhibited activity against MtbGS in primary screening of biosynthetic assay. Subsequent fractionation was carried out in organic solvents. Out of all these, two fractions (fraction D and K) are exhibiting inhibitory activity againstglutamine synthetase activity. These fractions D and K are inhibiting 74% and 44% respectively at 7.5 mg/ml concentrations. The determined ICvalue of the fraction K is found to be 4.5 mg/ml from the dose response curve against the purifiedGlutamine Synthetase. The ICvalue forBCG is 1.56 μg/ml. It was observed that there was no significant effect on proliferation of HL-60 cell line at 10×MIC levels of the hits. This data indicated that these compounds could be initially considered to be safe.